The road was closed for five hours for an investigation to take place.
Anyone with information is asked to call police on 101 quoting log 716, 26 November.
2 elderly people have serious injuries
Officers were called to the village of Bowd between Newton Poppleford and Sidbury at 7.12pm last night (Monday 26th November)
The crash involved a Rover 25 and an Audi R8.
2 people in the Rover, a 74-year-old woman and a 99-year-old man sustained serious injuries and were taken to the RD&E by ambulance.
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