It happened near Plymouth on Sunday night.
Police are looking for witnesses after a serious collision.
Emergency services were called to the westbound carriageway at the Manadon slip-off at 10.45pm last night (Sunday 15th December).
A white Renault Traffic van was in collision with a blue Peugeot 109.
One of the male occupants of the Peugeot was taken to Derriford Hospital with serious head injuries. The passenger of the Peugeot and the driver of the van were also taken to hospital as a result of their injuries.
Any witnesses to the collision or who had seen the vehicles on the off-slip prior to the collision are asked to contact the Police by calling 101 quoting log 922 of 15th December.
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